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Related Experiment Videos

Evolution of protein structures and functions.

Lisa N Kinch1, Nick V Grishin

  • 1Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9050, USA. lkinch@chop.swmed.edu

Current Opinion in Structural Biology
|July 20, 2002
PubMed
Summary
This summary is machine-generated.

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Protein structures evolve through domain fusion and mutation, showcasing fold plasticity and functional adaptation. This highlights the stability of protein folds and their response to functional demands.

Area of Science:

  • Structural biology
  • Protein evolution
  • Molecular biology

Background:

  • The vast number of known protein sequences and structures reveals evolving three-dimensional architectures.
  • Emerging examples demonstrate the inherent plasticity and robustness of protein folds.

Purpose of the Study:

  • To elucidate the mechanisms driving changes in protein fold evolution.
  • To connect observed structural changes with protein function and stability.

Main Methods:

  • Analysis of protein sequence and structure databases.
  • Identification of evolutionary patterns such as domain duplication and fusion.
  • Comparative analysis of mutated protein variants.

Main Results:

Related Experiment Videos

  • Observed evolution of protein folds through domain fusion events.
  • Subsequent divergence of fused domains via mutation.
  • Correlation between structural plasticity and functional requirements.

    • Conclusions:

    • Protein fold evolution is characterized by domain fusion and mutational divergence.
    • These evolutionary pathways underscore the stability of protein folds.
    • Changes in protein structure are driven by the need to meet functional requirements.