Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial working memory span, delayed response and executive function in schizophrenia.

Jeanyung Chey1, Junghee Lee, Yong-Sik Kim

  • 1Department of Psychology, Seoul National University, Kwanak-gu 599, Seoul 151-746, South Korea. jychey@snu.ac.kr

Psychiatry Research
|July 20, 2002
PubMed
Summary

Schizophrenia patients show deficits in spatial working memory span (SWMS) and immediate memory span. These working memory impairments contribute to executive function deficits, particularly in visuospatial tasks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer's disease.

Signal transduction and targeted therapy·2026
Same author

Basal forebrain parvalbumin neuron dysfunction links network oscillation deficits to hippocampal pathology in Alzheimer's disease.

Research square·2026
Same author

Correction: Kim et al. Identification of <i>GREM-1</i> and <i>GAS6</i> as Specific Biomarkers for Cancer-Associated Fibroblasts Derived from Patients with Non-Small-Cell Lung Cancer. <i>Cancers</i> 2025, <i>17</i>, 2858.

Cancers·2026
Same author

Histogram analysis of coronal magnetic resonance imaging of condyle in female patients with jaw deformity.

Journal of stomatology, oral and maxillofacial surgery·2026
Same author

Optimizing lymph node dissection for accurate nodal staging in early-stage esophageal squamous cell carcinoma: a multicenter study.

Esophagus : official journal of the Japan Esophageal Society·2026
Same author

Relationships between cognition and daily functioning in adults with bipolar disorder: A systematic review and multilevel meta-analysis.

Psychological bulletin·2026

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Schizophrenia is associated with cognitive impairments, including executive function deficits.
  • Working memory capacity is crucial for executive functions, particularly in visuospatial domains.
  • Previous research suggests verbal working memory deficits in schizophrenia, but spatial working memory requires further investigation.

Purpose of the Study:

  • To investigate spatial working memory span (SWMS) and immediate memory span in schizophrenia patients.
  • To examine the contribution of these memory spans to visuospatial executive function deficits.
  • To explore the relationship between working memory, executive function, and prefrontal tasks in schizophrenia.

Main Methods:

  • Assessed SWMS and immediate memory span (spatial span forward and backward) in 16 schizophrenia patients and 16 controls.

Related Experiment Videos

  • Evaluated executive function using the self-ordered pointing task (SOPT).
  • Administered the spatial delayed response task to assess prefrontal function.

    • Main Results:

    • Schizophrenia patients exhibited significantly reduced SWMS and spatial span (forward and backward) compared to controls.
    • Executive function (SOPT performance) was impaired in schizophrenia patients.
    • Backward spatial span deficit significantly explained the executive function impairment.
    • SWMS effectively explained impaired performance on the spatial delayed response task.

    Conclusions:

    • Working memory impairment in schizophrenia is general, affecting both verbal and spatial domains.
    • Backward spatial span is a key factor in the executive function deficits observed in schizophrenia.
    • SWMS is linked to prefrontal function, highlighting its role in schizophrenia-related cognitive decline.