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Apoptosis-inducing activity of synthetic intermediates of halichlorine
Midori Itoh1, Jun Kuwahara, Kohji Itoh
1Institute for Medicinal Resources, University of Tokushima, Sho-machi 1-78, 770-8505, Tokushima, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 20, 2002
Abstract:
Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.