Related Experiment Videos
Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids
Bertrand Cottineau1, Patrick Toto, Christophe Marot
1Institut de Chimie Organique et Analytique, Université d'Orléans, BP 6759, 45067 Cedex 2, Orléans, France.
Bioorganic & Medicinal Chemistry Letters
|July 20, 2002
Abstract:
The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.