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3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists
Jun Yuan1, Michael Gulianello, Stéphane De Lombaert
1Neurogen Corporation, 35Northeast Industrial Road, Branford, CT 06405, USA.
Bioorganic & Medicinal Chemistry Letters
|July 20, 2002
Abstract:
The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.