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Elucidation of solid-state complexation in ground mixtures of cholic acid and guest compounds
Toshio Oguchi1, Yuichi Tozuka, Takehisa Hanawa
1Graduate School of Pharmaceutical Sciences, Chiba University, Japan. toguchi@p.chiba-u.ac.jp
Chemical & Pharmaceutical Bulletin
|July 20, 2002
Abstract:
The solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA-MPB was 1 : 1 while that of CA-IBP was 2 : 1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules.