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Atopic dermatitis: review 2000 to January 2001
Arnold P Oranje1, Flora B de Waard-van der Spek
1Department of Dermatology, Sophia Children's Hospital (Pediatric Dermatology), Erasmus MC, Rotterdam, The Netherlands. aoranje@inter.nl.net
Current Opinion in Pediatrics
|July 20, 2002
Summary
Atopic dermatitis is a chronic skin condition with rising prevalence. While mild cases often resolve, severe cases significantly impact life, and new adult-onset cases are emerging.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Atopic dermatitis is a chronic, inflammatory skin disease with unknown etiology.
- Its prevalence is increasing globally, particularly in industrialized nations.
- The 'hygiene theory' is a leading hypothesis for the rising incidence.
Purpose of the Study:
- To review current understanding of atopic dermatitis based on literature from February 2000 to January 2001.
- To discuss the disease's clinical features, impact, and emerging subgroups.
- To evaluate diagnostic tools and the role of diet.
Main Methods:
- Literature review of articles published between February 1, 2000, and January 31, 2001.
- Analysis of clinical features, prevalence trends, and potential causes.
- Examination of diagnostic methods like the Atopy Patch Test and dietary considerations.
Main Results:
- Atopic dermatitis exhibits age-related clinical manifestations, with mild cases (60%) often resolving.
- A newly identified subgroup of adult-onset atopic dermatitis has been observed.
- The role of food allergy and diet is debated, especially in children under five.
- The Atopy Patch Test shows promise but remains experimental with limitations.
Conclusions:
- Atopic dermatitis is a complex condition with significant morbidity and socioeconomic costs.
- Further research is needed to understand its rising prevalence and identify effective treatments.
- Early diagnosis and management are crucial, despite ongoing controversies regarding diet and specific tests.