Late-onset allergy-like reactions to X-ray contrast media

The purpose of the present review is to describe recent insight into the pathomechanism of the late-onset allergy-like reactions which affect 2-3% of contrast medium-exposed patients, and to give advice regarding prophylactic measures to avoid recurrence of such reactions.

It is well recognized that the majority of contrast media-induced late-onset reactions are cutaneous reactions of the maculopapular, urticarial and angioedema types, with occasional occurrence of more serious, bullous eruptions. Recent findings strongly indicate that these reactions are T cell-mediated. The current evidences for this concept are the described clinical symptoms; the high incidence of reactions in interleukin-2-treated patients; the positive results from skin, provocation and lymphocyte transformation testing of affected patients; and the histopathology of skin eruptions and positive skin test sites.

On the basis of this new knowledge, several prophylactic measures are proposed to avoid repeat reactions in patients with previous late-onset contrast medium reactions. All persons receiving contrast media should be informed that transient skin reactions may develop up to 7 days after contrast medium exposure. Those who experience such reactions should be advised to see an allergist for diagnosis of the reaction. Skin testing with a panel of different contrast media appears to be useful for confirming the presence of an allergic reaction and for identifying alternative contrast media that can be safely used. For undiagnosed persons, a contrast medium that is structurally different from the product that precipitated the reaction should be chosen if re-exposure to contrast media is required. Pretreatment with corticosteroids may also be tried, although its protective effect has not been systematically studied.