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COL1A1-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcoma protuberans and its
Georges Maire1, Florence Pédeutour, Jean-Michel Coindre
1UF Recherche clinique 0952 and Laboratoire de Cytogénétique, Université de Bordeaux II and Institut Bergonié, France.
The American Journal of Surgical Pathology
|July 20, 2002
Abstract:
Granular cell variant of dermatofibrosarcoma protuberans is very rare with only one report of two cases. We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue. This case analysis demonstrated the utility of molecular genetics as a powerful tool for the diagnosis of atypical forms of dermatofibrosarcoma protuberans.