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[Modification of human osteoblasts by various analgesics].

G Matziolis1, H M Rau, P Klever

  • 1Universitätsklinikums der RWTH Aachen, Berlin.

Der Unfallchirurg
|July 23, 2002
PubMed
Summary

Tramadol did not show negative effects on osteoblast activity in vitro, even at high concentrations. Diclofenac, however, significantly reduced osteoblast proliferation at therapeutically relevant levels, potentially impacting fracture healing.

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Area of Science:

  • Orthopedics
  • Pharmacology
  • Cell Biology

Context:

  • Analgesia is crucial for fracture treatment.
  • Concerns exist regarding the impact of common analgesics like Tramadol and Diclofenac on bone healing.
  • Osteoblast function is critical for fracture repair.

Purpose:

  • To investigate the in vitro effects of Tramadol and Diclofenac on human osteoblast proliferation and mitochondrial activity.
  • To compare the effects of these analgesics at concentrations relevant to therapeutic use.

Summary:

  • Human osteoblasts were incubated with varying concentrations of Tramadol and Diclofenac.
  • Both analgesics demonstrated a dose-dependent decrease in cell proliferation.
  • Tramadol's significant effect occurred at concentrations far exceeding therapeutic levels, while Diclofenac impacted proliferation at clinically relevant concentrations.

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  • Cell viability strongly correlated with cell proliferation (R=0.95).

    • Impact:

    • Results suggest Tramadol is unlikely to negatively affect osteoblast activity in vivo.
    • Diclofenac may impede fracture healing at therapeutic concentrations, potentially prolonging recovery in complex cases like pseudarthrosis revision.