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Related Experiment Videos

Esomeprazole: a clinical review.

Thomas J Johnson1, Dennis D Hedge

  • 1South Dakota State University, Brookings, USA. thomas.johnson@mckennan.org

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|July 23, 2002
PubMed
Summary

Esomeprazole, an S-isomer proton-pump inhibitor (PPI), effectively treats GERD and H. pylori infections. Its unique isomer may offer improved pharmacokinetics and pharmacodynamics compared to other PPIs.

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Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Esomeprazole is the S-isomer of omeprazole, a proton-pump inhibitor (PPI).
  • It is FDA-approved for symptomatic gastroesophageal reflux disease (GERD), erosive esophagitis healing/maintenance, and H. pylori eradication.
  • As the sole active isomer PPI, it may offer enhanced pharmacokinetic and pharmacodynamic properties.

Purpose of the Study:

  • To review the pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, and adverse effects of esomeprazole.
  • To compare esomeprazole's characteristics with other proton-pump inhibitors.
  • To evaluate esomeprazole's role in managing GERD and H. pylori infections.

Main Methods:

  • Review of existing pharmacological and clinical data on esomeprazole.
  • Analysis of pharmacokinetic and pharmacodynamic studies.
  • Evaluation of clinical trial results for efficacy and safety.

Main Results:

  • Esomeprazole maintains intragastric pH > 4 for longer durations than other PPIs.
  • Clinical studies demonstrate equivalent safety and efficacy to other drugs in its class.
  • Effective dosages include 20 or 40 mg daily for GERD; 40 mg with antibiotics for H. pylori.
  • Common adverse effects include headache, respiratory infection, and abdominal symptoms.

Conclusions:

  • Esomeprazole is an effective treatment for GERD and H. pylori eradication.
  • Its pharmacokinetic profile may offer advantages over omeprazole in certain patients.
  • It presents a favorable safety profile with limited drug interactions.

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