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Staking out novelty on the genomic frontier
Kerry E Quinn-Senger1, Ravi Ramachandran, Joseph A Rininger
1CuraGen Corporation, Department of Collaborative Research, 555 Long Wharf Drive, New Haven, Connecticut 06511, USA.
Current Opinion in Chemical Biology
|July 23, 2002
Summary
Genomics advances enable new drug discovery by identifying novel genes and pathways. Integrating genomics with proteomics improves drug tolerance prediction and therapeutic development.
Area of Science:
- Genomics and Bioinformatics
- Systems Biology
- Pharmacogenomics
Background:
- Genomics has rapidly advanced, enabling comprehensive genome analysis and novel gene discovery.
- High-throughput technologies facilitate biological pathway construction and transcriptome analysis.
Purpose of the Study:
- To highlight recent advancements in genomics and their impact on drug discovery and development.
- To explore the integration of genomics, proteomics, and pathway mapping for improved therapeutic strategies.
Main Methods:
- Global assessment and classification of genome content.
- High-throughput biological pathway construction.
- Systematic identification of unpredicted genes and in vitro creation of novel functional motifs.
- Global transcriptome surveys.
- Integration of proteomics with expression data for pathway mapping.
Main Results:
- Genomics enables the discovery of previously unpredicted genes and novel functional motifs.
- Transcriptome analysis has spurred the growth of pharmacogenomics and toxicogenomics.
- Integration of genomics and proteomics facilitates the identification of novel drug targets and prediction of drug tolerance.
Conclusions:
- Genomics technologies, combined with conventional methods, promise more tolerable drugs and better understanding of patient populations.
- Pathway mapping integrating proteomics and expression data will revolutionize therapeutic discovery by revealing cross-biological interactions.