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Proteomics in drug discovery.

Jonathan Burbaum1, Gabriela M Tobal

  • 1ActivX Biosciences, Inc., 11025 North Torrey Pines Road, Suite 120, La Jolla, CA 92037, USA. jonb@activx.com

Current Opinion in Chemical Biology
|July 23, 2002
PubMed
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Proteomics and advanced biotechnologies accelerate drug discovery. These methods overcome interdisciplinary challenges, enhancing the efficiency of developing new medicines.

Area of Science:

  • Biotechnology and Bioinformatics
  • Drug Discovery and Development
  • Proteomics and Genomics

Background:

  • Drug discovery is a lengthy procedure requiring diverse tools.
  • Biotechnologies like genomics and proteomics aim to expedite this process.
  • Proteomics development involves traditional (biology, chemistry) and emerging (automation, bioinformatics) fields.

Purpose of the Study:

  • To highlight the role of proteomics in accelerating drug discovery.
  • To discuss the interdisciplinary challenges and emergent technologies in proteomics.
  • To demonstrate how proteomics advances drug development.

Main Methods:

  • Utilizing genomics, proteomics, and cellular/organismic methodologies.
  • Employing emergent technologies such as mass spectrometry and protein arrays.

Related Experiment Videos

  • Integrating high-throughput automation and bioinformatics.

    • Main Results:

    • Proteomics development integrates traditional and emerging scientific disciplines.
    • Advanced technologies like mass spectrometry and protein arrays are key.
    • These techniques enhance the application of proteomics in drug discovery.

    Conclusions:

    • Proteomics, supported by advanced biotechnologies, is crucial for accelerating drug discovery.
    • Overcoming interdisciplinary challenges through integrated technologies is vital.
    • The continuous evolution of proteomics techniques significantly advances pharmaceutical development.