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The path to personalized medicine.

Joanne M Meyer1, Geoffrey S Ginsburg

  • 1Millennium Pharmaceuticals, Inc., 45 Sidney Street, Cambridge, MA 02139, USA. meyer@mpi.com

Current Opinion in Chemical Biology
|July 23, 2002
PubMed
Summary

Human genome research advances personalized medicine by identifying molecular markers for disease prediction and drug response. Successful programs require biomarker validation and integration with drug discovery and clinical development.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Translational Medicine

Background:

  • Personalized medicine utilizes individual molecular profiles to tailor medical treatment.
  • Human genome research is foundational to advances in personalized medicine.
  • Molecular markers are crucial for various clinical applications.

Purpose of the Study:

  • To highlight the role of human genome research in advancing personalized medicine.
  • To outline the importance of molecular markers in clinical practice.
  • To emphasize the need for integrated strategies in personalized medicine research.

Main Methods:

  • Review of human genome research findings.
  • Identification and categorization of molecular markers.
  • Analysis of requirements for successful personalized medicine programs.

Main Results:

  • Human genome research has enabled the identification of numerous molecular markers.
  • These markers support predisposition testing, disease screening, prognostic assessment, and drug response prediction.
  • Effective personalized medicine necessitates robust biomarker development and validation.

Conclusions:

  • Personalized medicine is significantly advanced by human genome research.
  • Biomarker discovery and validation are critical components.
  • Coordinated efforts in drug discovery and clinical development are essential for successful personalized medicine implementation.

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