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Evaluation of inotropic changes in ventricular function by NOGA mapping: comparison with echocardiography
Jonathan Lessick1, Gal Hayam, Asaph Zaretsky
1Department of Cardiology, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 31096, Israel. : j_lessick@rambam.health.gov.il
Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 23, 2002
Summary
NOGA electromechanical mapping accurately assesses left ventricular (LV) function and contractility changes, closely correlating with echocardiography. However, it may underestimate LV function at higher levels.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Accurate assessment of left ventricular (LV) function is crucial for treatment decisions in cardiac catheterization.
- NOGA electromechanical mapping offers a method to evaluate LV contraction, but its quantitative analysis and comparison to standard methods require further investigation.
Purpose of the Study:
- To evaluate the accuracy of NOGA-based regional and global LV function assessment.
- To compare NOGA's ability to detect pharmacologically induced contractility changes against echocardiography.
Main Methods:
- Ten anesthetized pigs underwent NOGA electromechanical mapping and echocardiography at baseline, during dobutamine infusion, and after propranolol administration.
- Analysis focused on NOGA's local shortening (LS) algorithm and ejection fraction (EF) compared to echocardiographic measurements.
Main Results:
- NOGA LS and EF demonstrated consistent increases with dobutamine and decreases with propranolol, reflecting changes in contractility.
- High correlations were observed between NOGA LS and echocardiographic circumferential shortening (r > 0.80), and between NOGA EF and echocardiographic EF (r = 0.92).
- While NOGA correlates well, it tends to underestimate LV function at the upper range.
Conclusions:
- NOGA electromechanical mapping provides a reliable assessment of global and regional LV function.
- The NOGA system is sensitive to pharmacologically induced alterations in cardiac contractility.
- NOGA's quantitative analysis of LV function shows strong correlation with echocardiography, though absolute values may differ, particularly at higher function levels.