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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Molecular basis of the attenuation exhibited by molecularly cloned highly passaged chicken anemia virus isolates

Daniel Todd1, Alistair N J Scott, Neris W Ball

  • 1Department of Agriculture and Rural Development for Northern Ireland, Veterinary Sciences Division, the Queen's University of Belfast, Stormont, United Kingdom. Daniel.Todd@dardni.gov.uk

Journal of Virology
|July 23, 2002
PubMed

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...