Related Experiment Video

Updated: Sep 29, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

Prognostic value of doppler-ultrasonography in hepatic veno-occlusive disease

Nathalie Lassau1, Anne Auperin, Jerome Leclere

  • 1Department of Medical Imaging, Pediatric Bone Marrow Transplantation Unit, Institut Gustave Roussy, Villejuif, France. lasaau@pobox.igr.fr

Transplantation
|July 23, 2002
PubMed

Insights

This study introduces a noninvasive ultrasonography (US) and Doppler method to predict the severity of veno-occlusive disease (VOD) in children undergoing stem cell transplantation. The para-umbilical vein flow criterion proved highly significant in grading VOD severity.

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Medical Imaging

Background:

  • Veno-occlusive disease (VOD) severity is traditionally graded retrospectively using clinical and biological markers.
  • A need exists for a noninvasive method to predict VOD severity at diagnosis.

Purpose of the Study:

  • To evaluate a novel noninvasive ultrasonography (US) and Doppler method for predicting veno-occlusive disease (VOD) severity in pediatric patients.
  • To establish the prognostic significance of US and Doppler parameters in VOD grading.

Main Methods:

  • Seventy-one children receiving busulfan-based myeloablative therapy before hematopoietic stem cell transplantation were studied.
  • Baseline and post-transplantation US and Doppler examinations were performed.
  • Seven US and seven Doppler criteria were assessed, generating US, Doppler, and combined DUS scores.

Main Results:

  • Univariate analysis showed correlations between US criteria, Doppler criteria, and VOD severity.
  • Multivariate analysis identified splenomegaly, ascites, and para-umbilical vein flow as significant predictors.
  • Para-umbilical vein flow was the sole criterion significantly associated with VOD grade (P=0.0001); a DUS score >9 predicted grade 2 or 3 VOD.

Conclusions:

  • Post-transplant US and Doppler examinations possess prognostic value for VOD grading.
  • This noninvasive approach aids in predicting VOD severity at the time of diagnosis.
Abstract

More Related Videos

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge09:32

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge

Published on: January 20, 2023

Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation05:49

Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation

Published on: May 16, 2025

Related Concept Videos

Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...