Related Experiment Video

Updated: Sep 30, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

[Are there effects due to the existence of coronary collateral circulation on left ventricular function in patients

Izzet Tandoğan1, Tayfun Altinok, Halil Aslan

  • 1Inönü Universitesi Tip Fakültesi Turgut Ozal Tip Merkezi Kardiyoloji ve Radyoloji Anabilim Dallari, Malatya, Ankara. i.tandogan@ttnet.net.tr

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|July 24, 2002
PubMed

Insights

Coronary collateral circulation (CCC) does not prevent left ventricular dysfunction in coronary artery disease. Advanced CCC stages correlate with worse ventricular function, possibly due to more severe underlying disease.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Ischemic Heart Disease Research

Background:

  • Coronary artery disease (CAD) impacts left ventricular (LV) function.
  • The role of coronary collateral circulation (CCC) in mitigating LV dysfunction in CAD remains debated.
  • Understanding CCC's effect is crucial for managing ischemic heart disease.

Purpose of the Study:

  • To investigate the impact of coronary collateral circulation (CCC) on left ventricular function in patients with ischemic heart disease.
  • To determine if CCC offers a protective effect against LV dysfunction in the context of single-vessel coronary artery disease.
  • To explore the relationship between the severity of collateralization and LV regional wall motion and ejection fraction.

Main Methods:

  • Seventy-six patients with single-vessel disease and significant left anterior descending artery stenosis were enrolled.
  • Coronary collateral circulation was assessed using the Rentrop classification (0-3).
  • Left ventricular function was evaluated via echocardiography, measuring regional wall motion score and ejection fraction.

Main Results:

  • No significant difference in regional wall motion score or ejection fraction was found between patients with and without CCC.
  • A positive correlation was observed between higher Rentrop classes (indicating better CCC) and worse regional wall motion scores.
  • Patients with the most advanced CCC (Class 3) exhibited the highest wall motion scores, suggesting impaired function.

Conclusions:

  • Coronary collateral circulation does not appear to have a preventive effect on left ventricular function in patients with coronary artery disease.
  • Worsening left ventricular function was paradoxically associated with increased stages of CCC.
  • This finding may suggest that well-developed collateral circulation is a compensatory response to more severe coronary artery disease.
Abstract

More Related Videos

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...