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[Factor X deficiency and pregnancy].

K Rezig1, N Diar, D Benabidallah

  • 1Service d'anesthésie-réanimation, CHI André Grégoire, 93150 Montreuil, France. kamel.rezig@chi-andre-gregoire.fr

Annales Francaises D'Anesthesie Et De Reanimation
|July 24, 2002
PubMed
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This case study shows that prophylactic treatment with prothrombin complex concentrates effectively prevents severe bleeding in pregnant women with factor X deficiency, ensuring a healthy mother and baby.

Area of Science:

  • Hematology
  • Genetics
  • Obstetrics

Context:

  • Factor X deficiency is a rare autosomal recessive inherited coagulation disorder.
  • Pregnancy in women with factor X deficiency poses risks for adverse fetal outcomes.
  • The prevalence of factor X deficiency is estimated at 1:500,000 in homozygous form and 1:500 to 1:2000 in heterozygous form.

Purpose:

  • To report a case of successful pregnancy management in a woman with factor X deficiency.
  • To evaluate the efficacy of prophylactic prothrombin complex concentrates during labor and delivery.

Summary:

  • A pregnant woman with factor X deficiency received prophylactic treatment with prothrombin complex concentrates (Kaskadil) starting early in labor.
  • An initial infusion of 40 UI/kg of factor X was administered, followed by 20 UI/kg every 24 hours for three days.

Related Experiment Videos

  • Maternal coagulation was monitored throughout labor and the postpartum period.

    • Impact:

    • The patient delivered a healthy baby at 33 weeks of gestation without any abnormal bleeding episodes.
    • Prophylactic therapy with prothrombin complex concentrates successfully prevented severe hemorrhages during labor and delivery in this case.
    • This case highlights the importance of early prophylactic treatment for managing factor X deficiency during pregnancy.