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Correlation between changes in stroke volume and the paced intracardiac electrogram.

G Schreier1, P Kastner, S Schaffellner

  • 1ARC Seibersdorf research GmbH, Graz Office, Austria. guenter.schreier@arcs.ac.at

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|July 24, 2002
PubMed
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Paced intracardiac electrograms show a strong correlation with cardiac haemodynamics, specifically stroke volume changes. This suggests that electrograms can non-invasively assess heart function and geometry in heart transplant patients.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Cardiac haemodynamics are crucial for assessing heart function.
  • Intracardiac electrograms provide electrical information from within the heart.

Purpose of the Study:

  • To investigate the relationship between cardiac haemodynamics and intracardiac electrogram parameters during ventricular pacing.
  • To determine if electrograms can non-invasively reflect haemodynamic changes.

Main Methods:

  • Simultaneous monitoring of intracardiac electrograms and cardiac haemodynamics in 10 heart transplant patients.
  • Induction of various haemodynamic states via pacemaker programming and table tilting.
  • Analysis of R wave slew rate from evoked responses and stroke volume changes using linear regression.

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Main Results:

  • A strong, inverse, and highly significant correlation (r = -0.93, P < 0.0001) was found between relative stroke volume changes and relative R wave slew rate changes.
  • This correlation held true for variations induced by pacing rate and postural changes.

Conclusions:

  • Paced intracardiac electrograms accurately reflect changes in heart size and geometry.
  • Telemetrically recorded electrograms offer a non-invasive method for assessing cardiac haemodynamics.