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Published on: December 5, 2020
Synthesis of some new thiazole derivatives. antifungal activity and ultrastructure changes of some mycotoxin
1Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Cairo, Egypt.
Abstract:
Several new thiazoles 2-7,10-12; 2,3-diphenyl-5-(2-thienyl)imidazo[2,1-b]thiazole 8, 3,5-di-(2-thienyl)imidazo[2,1-b]thiazole 9 and 4-amino-2-imino-6-(2-thienyl)thiazolo[3,2-a] pyrimidine 13 and 6-(2-thienyl)-3H-thiazolo[3,2-a]pyrimidin-2,4-diones 14 have been synthesized. The prepared compounds were evaluated for their in-vitro antifungal activity, compared with Tioconazol fungicide. The strong antifungal activity is elicited by compounds 5 and 8. The most active compound 5 was found to induce changes in the ultrastructure of mycotoxin producing fungi (Aspergillus flavus and Aspergillus ochraceus), this was observed by both scanning and transmission electron microscopy.
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