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Related Experiment Videos

Is there a common cold constitution?

Thomas M Ball1, Catharine J Holberg, Fernando D Martinez

  • 1Department of Pediatrics and the Steele Memorial Children's Research Center, University of Arizona College of Medicine, Tucson 85724-5073, USA. tball@u.arizona.edu

Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association
|July 24, 2002
PubMed
Summary
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Children with frequent common colds in early childhood are likely to continue experiencing them throughout childhood. This suggests a "common cold constitution" influences susceptibility to frequent infections.

Area of Science:

  • Pediatric Respiratory Health
  • Immunology
  • Epidemiology

Background:

  • Susceptibility to common cold illness may be influenced by inherent constitutional factors.
  • Understanding persistent common cold frequency in children is crucial for public health insights.

Purpose of the Study:

  • To investigate whether the tendency for frequent common colds persists throughout childhood.
  • To explore potential underlying biological markers associated with persistent common cold susceptibility.

Main Methods:

  • Prospective cohort study of 1246 children from birth (Tucson Children's Respiratory Study).
  • Parental questionnaires collected data on frequent colds (≥4 per year) at ages 2, 3, 6, 8, 11, and 13.
  • Ex vivo interferon-gamma responses measured at 9 months and 11 years of age.

Related Experiment Videos

Main Results:

  • Children with frequent colds at ages 2-3 were significantly more likely to have frequent colds at subsequent ages up to 13 (RR 2.1-2.8).
  • Lower interferon-gamma titers at 9 months and 11 years were observed in children with persistent frequent colds.
  • These findings indicate a stable susceptibility to common colds across childhood.

Conclusions:

  • The study supports the concept of a
  • common cold constitution
  • indicating some children are inherently more prone to frequent infections or symptomatic illness.
  • Early childhood indicators may predict long-term susceptibility to common colds.