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Updated: Jul 28, 2026

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
Published on: September 15, 2016
Two new HLA-B alleles, B*4422 and B*4704, identified in a study of families with autoimmunity
S E Grams1, P V Moonsamy, C Mano
1Children's Hospital Oakland Research Institute, Oakland, California, USA.
Abstract:
HLA-B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA-B*4422 and HLA-B*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion-like events play an important role in generating HLA allelic diversity. The identification of these new alleles brings the total number of HLA-B alleles to 465.
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