Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The GABAergic system in schizophrenia.

Brian Paul Blum1, J John Mann

  • 1Columbia University College of Physicians and Surgeons, Department of Psychiatry, New York State Psychiatric Institute, Department of Neuroscience, New York 10032, USA. bb453@columbia.edu

The International Journal of Neuropsychopharmacology
|July 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depression-related anterior cingulate prefrontal resting state connectivity normalizes following cognitive behavioral therapy.

European psychiatry : the journal of the Association of European Psychiatrists·2020
Same author

Psychosocial risk factors and outcomes associated with suicide attempts in childhood: A retrospective study.

Journal of psychiatric research·2020
Same author

Toward a Distinct Mental Disorder-Suicidal Behavior.

JAMA psychiatry·2020
Same author

Guidelines for the content and format of PET brain data in publications and archives: A consensus paper.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2020
Same author

Less NMDA Receptor Binding in Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex Associated With Reported Early-Life Adversity but Not Suicide.

The international journal of neuropsychopharmacology·2020
Same author

Interactions of the GABRG2 polymorphisms and childhood trauma on suicide attempt and related traits in depressed patients.

Journal of affective disorders·2020

Schizophrenia may involve a defect in the brain's gamma-amino butyric acid (GABA) system, particularly affecting specific interneurons in the frontal cortex. Research reviews biological studies supporting this neurotransmission theory.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurobiology

Background:

  • A theory from the 1970s suggests a gamma-amino butyric acid (GABA) neurotransmission defect in schizophrenia.
  • Extensive research has investigated various components of the GABAergic system in relation to schizophrenia.

Purpose of the Study:

  • To review post-mortem and biological studies on the GABAergic system in schizophrenia.
  • To identify specific defects within the GABAergic system implicated in schizophrenia.

Main Methods:

  • Review of post-mortem studies examining GABAergic system components.
  • Analysis of studies on GABA biosynthetic and catabolic enzymes.
  • Examination of studies on GABA transporters and receptors (GABAA, GABAB, benzodiazepine).
  • Inclusion of morphological and calcium-binding protein studies of GABAergic neurons.

Related Experiment Videos

Main Results:

  • Substantial evidence points to a defect in the frontal cortex's GABAergic system in schizophrenia.
  • This defect appears specifically localized to parvalbumin-class GABAergic interneurons.

Conclusions:

  • The findings support a targeted defect within a specific subset of GABAergic interneurons in the frontal cortex of individuals with schizophrenia.
  • This highlights the critical role of specific GABAergic pathways in the pathophysiology of schizophrenia.