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Updated: Sep 30, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
Published on: April 28, 2022
Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in
Yesim Ozarda Ilcol1, Osman Dönmez, Mahmut Yavuz
1Department of Biochemistry, Uludag University Medical School, Bursa, Turkey. ihulus@uludag.edu.tr
Objectives:
This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD).
Design And Methods:
Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD.
Results:
Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 microM in children and 18.2 +/- 1.4 microM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 microM and 10.8 +/- 1.4 microM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 micromoles in children and 260 +/- 18 micromoles in adults.
Conclusion:
CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.
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