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Is interstitial cystitis an infectious disease?

Susan K Keay1, J W Warren

  • 1Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. skeay@umaryland.edu

International Journal of Antimicrobial Agents
|July 24, 2002
PubMed
Summary
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Interstitial cystitis (IC) is a chronic bladder condition. Researchers found a toxic factor in most IC patients' urine that harms bladder cells, suggesting a new cause beyond infection.

Area of Science:

  • Urology
  • Cell Biology
  • Toxicology

Background:

  • Interstitial cystitis (IC) is a chronic bladder disorder with an unknown cause.
  • Previous research has not identified an infectious etiology for IC.

Purpose of the Study:

  • To investigate potential causes of Interstitial Cystitis (IC).
  • To identify factors in patient urine affecting bladder epithelial cells.

Main Methods:

  • Analysis of urine from Interstitial Cystitis (IC) patients.
  • In vitro studies on bladder epithelial cell proliferation.

Main Results:

  • A toxic factor was identified in the urine of approximately 95% of IC patients.
  • This toxic factor inhibits the normal proliferation of bladder epithelial cells.

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Conclusions:

  • The findings suggest a toxic factor, not infection, may cause Interstitial Cystitis (IC).
  • Further research is needed to determine the origin of this toxic factor (host cells or microorganism).