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Related Experiment Videos

Language lateralization in left-handed and ambidextrous people: fMRI data.

J P Szaflarski1, J R Binder, E T Possing

  • 1Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA. Jerzy.Szaflarski@uc.edu

Neurology
|July 24, 2002
PubMed
Summary

Atypical language lateralization is more common in non-right-handed individuals. Handedness and family history may influence language distribution, suggesting shared genetic factors.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Genetics

Background:

  • Most individuals exhibit left-hemispheric language dominance.
  • The incidence of atypical language distribution in non-right-handed subjects requires further investigation.
  • Understanding handedness and language lateralization can provide insights into brain organization.

Purpose of the Study:

  • To examine language distribution in non-right-handed subjects using fMRI.
  • To evaluate the relationship between personal handedness, family history of sinistrality, and language laterality index (LI).

Main Methods:

  • Whole-brain fMRI was used to study 50 healthy, non-right-handed participants.
  • Language activation and nonlinguistic control tasks were performed.
  • Language laterality index (LI) was calculated based on fMRI activation counts in various brain regions.

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Main Results:

  • Predominantly left-hemispheric activation occurred in 78% of subjects.
  • Atypical language lateralization (right-hemispheric or symmetric) was observed in 22% of subjects.
  • Significant associations were found between personal handedness, family history of sinistrality, age, and LI.

Conclusions:

  • The incidence of atypical language lateralization is higher in non-right-handed individuals compared to right-handed individuals.
  • Findings suggest a potential common genetic basis for handedness and language lateralization.
  • These results reinforce previous studies on language lateralization in left-handed populations.