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Crystallization and preliminary crystallographic analysis of human L-xylulose reductase
Ossama El-Kabbani1, Roland P T Chung, Syuhei Ishikura
1Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University(Parkville Campus), Parkville, Victoria 3052, Australia. ossama.el-kabbani@vcp.monash.edu.au
Abstract:
Human L-xylulose reductase was crystallized from buffered polyethylene glycol solutions using the hanging-drop vapour-diffusion method. The crystals diffract to 2.1 A resolution and belong to the orthorhombic P222 space group, with unit-cell parameters a = 72.9, b = 74.1, c = 87.9 A. This is the first crystallization report of a xylulose reductase that is identical to diacetyl reductase.