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Updated: Sep 30, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
[Arteriosclerotic renal artery stenosis. Significance, diagnosis and therapy options]
Markus Hollenbeck1, Adina Voiculescu, Gerd Rüdiger Hetzel
1Klinik für Nephrologie und Rheumatologie, Heinrich-Heine-Universität Düsseldorf. hollenbeck@kk-bottrop.de
Background:
Renal artery stenosis (RAS) can cause arterial hypertension and can lead to renal insufficiency. In 1999 16% of patients starting dialysis in Germany suffered from ischemic nephropathy.
Screening:
Cost-effective screening for RAS should be done by Doppler sonography or captopril renography. Doppler sonographic findings can be predictive in respect to progression of stenosis, renal atrophy and postinterventional course of hypertension and kidney survival.
Treatment:
The results of recent studies are helpful to select patients for preferential drug treatment or for interventional treatment.
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