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[Therapeutic effect of cyclophosphamide in patients with chronic glomerulonephritis with nephrotic syndrome]
Aim:
To analyse factors affecting the response to cyclophosphamide (CP) in patients suffering from chronic glomerulonephritis (CGN) with nephrotic syndrome (NS).
Material And Methods:
CP effectiveness was studied retrospectively in 32 patients with CGN and NS resistant to glucocorticosteroids. CP was given as intravenous injections daily or each other day in a dose 200 mg or as intravenous pulse therapy (1-3 times a months in a dose 800-1000).
Results:
28(87.5%) patients achieved a complete remission (CR) for 5 to 68 weeks (23.3 +/- 3.2 weeks) of treatment in accumulated CP dose (AD) from 2.4 to 35 g (11.8 +/- 1.5 g). One patient had a partial remission. An intensive therapy with CP provided a CR faster, probability of CR growing with increasing AD.
Conclusion:
CP treatment for CGN + NS for initial 1-2 months as daily intravenous injections in a dose 200 mg enabled faster achievement of the accumulated dose required for a CR. In the absence of CR on the accumulated dose 6-12 g it is early to conclude on inefficiency of CP.
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