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Intraadministration associations: conditional hyperalgesia elicited by morphine onset cues
Marta Sokolowska1, Shepard Siegel, Joseph A Kim
1Department of Psychology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.
Summary
Early drug cues (DOCs) can trigger hyperalgesia, contributing to morphine tolerance. This associative phenomenon suggests new addiction treatment strategies focusing on extinguishing these drug-related responses.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Exteroceptive cues can trigger compensatory responses to drugs, like morphine.
- Interoceptive early-drug onset cues (DOCs) may associate with later drug effects, forming intra-administration associations.
Purpose of the Study:
- To evaluate DOC-elicited conditional hyperalgesia in rats receiving morphine.
- To determine if DOC-elicited hyperalgesia contributes to morphine tolerance and its associative nature.
Main Methods:
- Rats were intravenously infused with morphine.
- Conditional hyperalgesia elicited by early-drug onset cues (DOCs) was measured.
Main Results:
- DOC-elicited hyperalgesia was observed in rats with a history of morphine administration.
- This hyperalgesia was found to contribute to tolerance to morphine's analgesic effects.
- The observed hyperalgesia was identified as an associative phenomenon, not a sensitized response.
Conclusions:
- Associative analyses of drug tolerance must account for DOC-elicited conditional responding.
- Extinction-based addiction treatments should include the extinction of DOC-elicited conditional responding.