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Ion chromatography studies of quaternary ammonium halide solutions and the determination of pharmaceuticals
1Department of Applied Chemistry, China Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
Abstract:
The feasibility of using ion chromatography (IC) in solutions containing quaternary ammoniums is studied. The results establish the applicability of IC for the determination of halide ions in a pharmaceutical sample without interferences by various excipient ions. For IC measurements with suitable methodical parameters, linearity is maintained over the range of 20 to 200 mg/L and 10.0 to 250 mg/L for the chloride and bromide of quaternary ammoniums, respectively. A comparison of the anion results obtained from differential pulse voltammetry shows good agreement.
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