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Mechanistic aspects of enzymatic carbohydrate epimerization
1Department of Chemistry, University of British Columbia, Vancouver, Canada.
Natural Product Reports
|July 26, 2002
Abstract:
Carbohydrate epimerases are enzymes that catalyze an inversion of stereochemistry at a stereogenic center in a sugar. This review focuses on the mechanistic strategies that are employed by this diverse family of enzymes, and is divided into the following sections: deprotonation/reprotonation, transient oxidation, cofactor independent, and mutarotation. The review is comprehensive up to Oct. 2001 and contains 216 references.