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Updated: Sep 30, 2026

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
Published on: November 29, 2018
Diaphragm versus diaphragm with spermicides for contraception
1Public Health and General Practice, Christchurch School of Medicine, Christchurch, New Zealand. lynley.cook@ xtra.co.nz
Background:
The diaphragm is usually used with a spermicide. However, some practitioners have suggested that spermicides offer no additional contraceptive protection and have advocated alternative guidelines for the use of diaphragms.
Objectives:
The objective of this review was to compare the effectiveness, safety and acceptability of the diaphragm with and without spermicide.
Search Strategy:
We searched MEDLINE, EMBASE, POPLINE, CINAHL, the Cochrane Controlled Trials Register, and reference lists of relevant articles. In addition, we contacted experts in the field to identify unpublished studies.
Selection Criteria:
Randomized controlled trials comparing women of reproductive age using the diaphragm with and without spermicide as the sole contraceptive method that reported clinical outcomes.
Data Collection And Analysis:
Two reviewers independently extracted data on outcomes and trial characteristics and any discrepancies were resolved by consensus or by consultation with the third reviewer. The results of the one identified study are presented descriptively.
Main Results:
We identified only one study. No significant difference was found in the pregnancy rates (with typical use or consistent use) or discontinuation rates between the diaphragm-with-spermicide and diaphragm-without-spermicide groups. However, this study failed to recruit the planned number of participants and was consequently underpowered.
Reviewer'S Conclusions:
We cannot distinguish between the contraceptive effectiveness of the diaphragm with and without spermicide.
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