Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotics for treating scrub typhus.

R Panpanich1, P Garner

  • 1Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. rpanpani@med.cmu.ac.th

The Cochrane Database of Systematic Reviews
|July 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Muscle abnormalities in Long COVID.

Nature communications·2025
Same author

Reply: Muscle abnormalities in Long COVID.

Nature communications·2025
Same author

Evaluating Cinchona bark and quinine for treating and preventing malaria.

Journal of the Royal Society of Medicine·2017
Same author

Evaluating Cinchona bark and quinine for treating and preventing malaria.

Journal of the Royal Society of Medicine·2017
Same author

Epidemiology of diabetic retinopathy and maculopathy in Africa: a systematic review.

Diabetic medicine : a journal of the British Diabetic Association·2012
Same author

Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review.

Parasitology·2009
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
Same journal

Non-pharmacological interventions for anxiety and depression in Parkinson's disease.

The Cochrane database of systematic reviews·2026
Same journal

Biologic drugs for induction and maintenance of remission in Crohn's disease: a network meta-analysis.

The Cochrane database of systematic reviews·2026
Same journal

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews·2026
See all related articles

Scrub typhus treatment with doxycycline or tetracycline showed no significant difference. Rifampicin may be more effective where standard antibiotics fail, offering a potential alternative for this bacterial infection.

Area of Science:

  • Infectious Diseases
  • Bacteriology
  • Clinical Pharmacology

Background:

  • Scrub typhus is a significant bacterial disease prevalent in Asia and the Pacific.
  • Commonly used antibiotics like chloramphenicol, tetracycline, and doxycycline are facing reported resistance.
  • Effective treatment options for scrub typhus are crucial due to emerging antibiotic resistance.

Purpose of the Study:

  • To systematically evaluate and compare the efficacy of different antibiotic regimens for treating scrub typhus.
  • To identify the most effective antibiotic treatments based on available clinical trial data.
  • To address the growing concern of antibiotic resistance in scrub typhus management.

Main Methods:

  • Conducted a comprehensive literature search across multiple databases including Cochrane, MEDLINE, EMBASE, and LILACS.

Related Experiment Videos

  • Included randomized and quasi-randomized controlled trials comparing antibiotic regimens in scrub typhus patients.
  • Data extraction and analysis were performed by two reviewers using Review Manager, calculating Relative Risk and confidence intervals.

    • Main Results:

    • Four trials with 451 adults met the inclusion criteria.
    • No significant difference was found between tetracycline and chloramphenicol, or between doxycycline and tetracycline in achieving afebrile status.
    • Rifampicin demonstrated higher efficacy than doxycycline in reducing fever, with no observed relapses.

    Conclusions:

    • Current limited data suggest no significant difference in efficacy between doxycycline and tetracycline for scrub typhus.
    • Rifampicin shows promise as an effective treatment in regions with poor response to standard anti-rickettsial drugs.
    • Further research is needed to confirm the efficacy of rifampicin and explore other treatment options.