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Homocysteine lowering interventions for peripheral arterial disease and bypass grafts

M Hansrani1, G Stansby

  • 1Department of Surgery, University of Newcastle upon Tyne, Elmwood House, Pirnmill View, Elm Tree Avenue, Stockton on Tees, Cleveland, UK, TS19 0TZ. m.d.hansrani@ncl.ac.uk

The Cochrane Database of Systematic Reviews
|July 26, 2002
PubMed

Insights

High homocysteine levels are linked to atherosclerosis. However, no studies currently exist to show if lowering homocysteine improves outcomes in peripheral arterial disease patients.

Area of Science:

  • Cardiovascular Research
  • Vascular Biology
  • Medical Interventions

Background:

  • Elevated plasma homocysteine (hyperhomocysteinaemia) is associated with atherosclerosis and poorer prognosis.
  • Homocysteine-lowering therapy is effective and inexpensive in healthy individuals.
  • The impact of homocysteine reduction on atherosclerosis progression and vessel patency post-treatment is unknown.

Purpose of the Study:

  • To assess the effects of homocysteine-lowering therapy on clinical progression in peripheral arterial disease (PAD) patients with hyperhomocysteinaemia.
  • To evaluate outcomes in PAD patients who underwent surgical or radiological intervention.

Main Methods:

  • Searched multiple databases including Cochrane registers, MEDLINE, and EMBASE.
  • Included randomized trials comparing homocysteine treatment versus no treatment in PAD patients.
  • Assessed trial quality and extracted data, including adverse events.

Main Results:

  • No randomized trials were available for analysis at the time of the review.

Conclusions:

  • There is an urgent need for well-constructed randomized trials.
  • Further research is required to determine the impact of homocysteine treatment in PAD patients.
Abstract

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