Related Experiment Videos
Non-canonical Wnt signalling and regulation of gastrulation movements
Masazumi Tada1, Miguel L Concha, Carl Philipp Heisenberg
1Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. m.tada@ucl.ac.uk
Seminars in Cell & Developmental Biology
|July 26, 2002
Abstract:
Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.