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Updated: Sep 30, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
Two-dimensional display and whole genome comparison of bacterial pathogen genomes of high G+C DNA content
Chad A Malloff1, Rachel C Fernandez, Edith M Dullaghan
1Department of Pathology, University of British Columbia, Canada.
Abstract:
High-resolution comparison of bacterial genomes facilitates the identification of the genetic changes responsible for clinically relevant phenotypes. For this purpose we have established a method for the display and comparison of high G+C bacterial genomes in two dimensions. Here we describe the application of two-dimensional bacterial genomic display to resolve the genomes of Bordetella pertussis, Mycobacterium avium and Mycobacterium tuberculosis, and its utility in strain comparison and detection of insertion and substitution mutations.
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