Electrocortical activity characteristic of vitamin B6 deficiency in the rat

Vitamin B6 deficiency is characterized by a variety of changes in the central nervous system. Weanling male white rats, fed different levels of pyridoxine for 60 days, showed consistent differences in both amplitude and frequency of their electrocortical activity. The more deficient animals displayed higher EEG voltages and a higher dominant frequency. These two effects were systematically related to pyridoxine intake and provided similar dose-response curves. The nutritional requirement for vitamin B6, as estimated from the EEG data, was in good agreement with that estimated from growth response data.