Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonexcitatory stimulus delivery improves left ventricular function in hearts with left bundle branch block.

Nassir F Marrouche1, Stephen V Pavia, Shaowei Zhuang

  • 1Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA.

Journal of Cardiovascular Electrophysiology
|July 26, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Success of Radiofrequency Catheter Ablation of Atrial Fibrillation: Does Obesity Influence the Outcomes?

Journal of atrial fibrillation·2017
Same author

JAFIB : A Comprehensive Resource for Afib ....

Journal of atrial fibrillation·2017
Same author

Atrial Fibrillation, Alcohol, Obesity and more....

Journal of atrial fibrillation·2017
Same author

World Atrial Fibrillation Awareness Day - It's About Time!

Journal of atrial fibrillation·2017
Same author

Thromboembolic and bleeding risks in patients undergoing atrial fibrillation ablation: oral anticoagulation perspectives.

Expert opinion on drug safety·2017
Same author

Foreword.

Cardiac electrophysiology clinics·2017

Nonexcitatory stimulation (NES) significantly improves left ventricular function in a heart failure model with left bundle branch block. NES is superior to biventricular pacing and does not impair diastolic function.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Animal Models

Background:

  • Preliminary studies suggest nonexcitatory stimulation (NES) enhances left ventricular (LV) function.
  • Heart failure animal models and isolated muscle preparations provide initial evidence for NES efficacy.

Purpose of the Study:

  • To compare the efficacy of NES with biventricular (BV) pacing in an animal model of left bundle branch block (LBBB).
  • To evaluate the impact of NES on LV hemodynamic parameters and diastolic function.

Main Methods:

  • Left bundle branch block (LBBB) was induced in eight pigs.
  • Measurements included LV pressures, LV dP/dtmax, aortic pulse pressure, LV ejection fraction, and mitral valve inflow (E/A waves).
  • Hemodynamic parameters were compared across pre-LBBB, post-LBBB (AAI pacing), BV pacing, NES, and combined BV+NES conditions.

Related Experiment Videos

Main Results:

  • NES significantly increased LV dP/dtmax, LV ejection fraction, and aortic pulse pressure compared to post-LBBB state.
  • NES demonstrated superior improvement in LV hemodynamic parameters compared to BV pacing.
  • No significant alterations in transmitral valve flow (E wave, A wave, E/A ratio) were observed with NES or BV pacing.

Conclusions:

  • Nonexcitatory stimulation (NES) is more effective than biventricular (BV) pacing in improving LV function in a LBBB animal model.
  • NES does not adversely affect transmitral valve flow, indicating preserved LV diastolic function.