Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

On-line parameter identification of systemic circulation using the delta operator.

Ryo Kosaka1, Yoshiyuki Sankai, Tomoaki Jikuya

  • 1Institute of Systems of Engineering Mechanics, University of Tsukuba, Tsukuba, Japan. kosaka@golem.kz.tsukuba.ac.jp

Artificial Organs
|July 26, 2002
PubMed
Summary

This study introduces a novel delta operator method for real-time identification of systemic circulation parameters like aortic compliance (Ca) and total peripheral resistance (Rp). This approach enables continuous monitoring of crucial cardiovascular dynamics for artificial heart applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Method for Predicting Recirculation by Sweep-Gas Control in Extracorporeal Membrane Oxygenation.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·2026
Same author

Real-world retention of nintedanib and factors associated with treatment discontinuation in connective tissue disease-associated interstitial lung disease: a retrospective cohort study of 92 patients.

Clinical rheumatology·2026
Same author

Glucocorticoid discontinuation in eosinophilic granulomatosis with polyangiitis treated with mepolizumab: associations with tapering patterns and initiation timing.

Frontiers in immunology·2026
Same author

Special feature: "current status and future development of organ preservation technology" novel techniques for assessing pulmonary function in cellular ex vivo lung perfusion: a republication of the review published in Japanese Journal of Artificial Organs.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026
Same author

Glucocorticoid reduction with baricitinib in rheumatoid arthritis refractory to prior therapies: a 24-week real-world analysis.

Frontiers in medicine·2026
Same author

Technical challenges and prospects for ex vivo heart perfusion: a republication of the review published in Japanese journal of artificial organs.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2026

Area of Science:

  • Biomedical Engineering
  • Physiological Modeling
  • System Identification

Background:

  • Effective medical care with artificial hearts requires real-time understanding of systemic circulation.
  • Current methods may not capture time-varying and unmeasured hemodynamic parameters accurately.

Purpose of the Study:

  • To propose and validate a new on-line parameter identification method for systemic circulation.
  • To enable real-time calculation of hemodynamics using measured aortic pressure and total flow.
  • To improve artificial heart management through accurate physiological parameter estimation.

Main Methods:

  • Development of a dynamic physiological model incorporating aortic compliance (Ca) and total peripheral resistance (Rp).
  • Application of a system identification method utilizing the delta operator for on-line parameter calculation.

Related Experiment Videos

  • Validation through computer simulations and animal experiments with a left ventricular assist system.

    • Main Results:

    • Computer simulations confirmed the effectiveness of the delta operator method for identifying physiological parameters.
    • On-line identification of physiological parameters was successfully achieved in animal experiments.
    • Accurate values for aortic compliance (Ca = 1.8 ml/mm Hg) and total peripheral resistance (Rp = 0.8 mm Hg s/ml) were identified.

    Conclusions:

    • The proposed delta operator method is effective for on-line parameter identification of systemic circulation.
    • This technique allows for real-time estimation of crucial hemodynamic parameters (Ca, Rp).
    • The findings support the application of this method in managing artificial heart systems and improving patient care.