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Amicrobial pustular dermatosis in two patients with immunological abnormalities
M Kuyama1, W Fujimoto, H Kambara
1Kawasaki Hospital, Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 719-0104, Japan. michiyo@po.harenet.ne.jp
Clinical and Experimental Dermatology
|July 26, 2002
Summary
Two women with autoimmune diseases developed severe amicrobial pustular dermatosis, a rare skin condition. Treatment with immunosuppressants and dapsone showed improvement, suggesting a link between autoimmune disorders and this pustular eruption.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Autoimmune diseases, such as discoid lupus erythematosus and Sjögren's syndrome, can manifest with complex dermatological conditions.
- Immunological abnormalities, including hypergammaglobulinemia and positive antinuclear antibodies, are associated with various autoimmune disorders.
Observation:
- Two female patients presented with severe amicrobial pustular dermatosis characterized by crusty, eroded, erythematous plaques with aseptic pustules on the face, back, and scalp.
- Histopathological findings revealed acanthosis, neutrophilic exocytosis, and dermal infiltration of neutrophils and lymphocytes with nuclear dust.
Findings:
- The patients were diagnosed with amicrobial pustulosis associated with autoimmune diseases.
- Combination therapy of oral prednisolone with either cyclosporin A or diaminodiphenylsulphone led to improvement in the eruptions.
Implications:
- Amicrobial pustular dermatosis may represent a cutaneous manifestation of underlying autoimmune diseases.
- Understanding the pathogenesis of this condition is crucial for developing targeted therapeutic strategies.
- This case report highlights the importance of considering dermatological evaluation in patients with autoimmune disorders presenting with unusual skin lesions.