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Depletion of bone-marrow cells due to deficiencies of trace elements
Hiroshi Oka1, Tohru Tani, Yozo Ebira
1First Department of Surgery, Shiga University of Medical Science, Tsukinowa, Shiga, Japan.
Abstract:
Male rats were divided into five diet-dependent groups: the Control group; two kinds of Zn-deficient diet groups with different amounts of Mn and Mg (the CLEA and OBS group); the Pair-fed group, where the body weight gain of the rats was restricted; and the OBS + Zn group. In those groups where the diets were deficient in Zn, Mn, and Mg, bone-marrow cells were suppressed and the peripheral reticulocyte count was decreased, but plasma corticosterone increased significantly. The OBS + Zn group demonstrated an improvement in the reticulocyte count and serum corticosterone level.