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Case report of meningoencephalitis during a concomitant mumps and parvovirus B19 infection

Shogo Yazawa1, Shoichiro Kawasaki, Chie Fujimoto

  • 1Department of Neurology, Miyazaki Prefectural Hospital of Nobeoka, Miyazaki, Japan. yazawa@postl.miyazaki-med.ac.jp

Clinical Neurology and Neurosurgery
|July 26, 2002
PubMed

Insights

A severe illness in a young man was caused by a dual infection with human parvovirus B19 and mumps virus. Prompt treatment with gamma-globulin and steroids led to a full recovery.

Area of Science:

  • Virology
  • Immunology
  • Clinical Medicine

Background:

  • Human parvovirus B19 and mumps virus are common viral pathogens.
  • Coinfections can sometimes lead to more severe clinical presentations.
  • Understanding the impact of viral coinfections is crucial for effective patient management.

Observation:

  • A 19-year-old male presented with prolonged fever, parotitis, lymphadenopathy, liver dysfunction, and leukocytopenia.
  • Neurological symptoms, including consciousness disturbance and seizures, developed 11 days after fever onset.
  • The patient exhibited elevated IgG and IgM antibodies for both parvovirus B19 and mumps, with detectable parvovirus B19 DNA in serum.

Findings:

  • The patient was diagnosed with a concurrent infection of human parvovirus B19 and mumps virus.
  • The combined infection was associated with severe systemic symptoms and neurological complications.
  • Treatment with gamma-globulin and corticosteroids resulted in complete clinical recovery.

Implications:

  • This case highlights the potential for severe outcomes in viral coinfections, even in immunocompetent individuals.
  • Early and accurate diagnosis of coinfections is essential for appropriate therapeutic interventions.
  • The successful treatment suggests that prompt medical management can effectively resolve severe manifestations of combined viral infections.

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