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Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man
Michael Kellner1, Alexander Yassouridis, Yun Hua
1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany. kellner@uke.uni-hamburg.de
Psychiatry Research
|July 26, 2002
Abstract:
Trait dissociation might influence the response to panicogens in normal controls. The behavioral effects of 25 microg of cholecystokinin tetrapeptide (CCK-4) were studied in 18 healthy men, nine each with high or low trait dissociation. Subjects with high trait dissociation showed a significantly lower increase of acute dissociative, anxiety and panic symptoms compared with subjects with low trait dissociation. Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate.