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The effect of losartan potassium on choroidal hemodynamics in healthy subjects
Tatiana Spicher1, Selim Orgül, Konstantin Gugleta
1University Eye Clinic, Basel, Switzerland.
Purpose:
To investigate the choroidal hemodynamic effects of losartan potassium, a specific angiotensin II subtype AT1 receptor antagonist.
Methods:
In this prospective, randomized, observer-masked, open-label placebo-controlled (lactose), two-period crossover study, the choroidal hemodynamic effects of a single oral 50-mg dose of losartan potassium were evaluated in 12 healthy subjects using choroidal laser Doppler flowmetry.
Results:
Perfusion pressure and the choroidal laser Doppler flowmetry parameters velocity, volume, and flux did not vary significantly compared with placebo (P = 0.33, 0.31, 0.74, and 0.61, respectively). Correcting choroidal laser Doppler flowmetry parameters for perfusion pressure in a covariance analysis did not change these results.
Conclusion:
A single oral 50-mg dose of the angiotensin II AT1 receptor antagonist losartan potassium given does not disturb the homeostasis of ocular perfusion pressure or choroidal blood flow in young healthy subjects.
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