Verruca vulgaris with CD30-positive lymphoid infiltrate: a case report

Expression of CD30 has been reported in reactive lymphoid cells that accompany some cutaneous viral infections. It is interpreted as a marker of lymphocyte activation in response to the infecting virus. We report on a case of viral wart presenting with an inflammatory infiltrate with numerous CD30+ atypical lymphoid cells. These cells comprised approximately 10% of the reactive cell population and showed a T-helper phenotype. Infection by human papillomavirus should be included among the causes of cutaneous CD30+ reactive lymphoid infiltrates.