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Updated: Aug 8, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

[Destabilization of the cellular genome while expressing early regulatory genes from oncoviruses]

L L Lukash

    Tsitologiia I Genetika
    |July 27, 2002
    PubMed

    Insights

    This review examines genetic instability in virus-infected cells, focusing on how viral genes, cellular responses, and DNA repair inhibition contribute to cancer development.

    Area of Science:

    • Virology
    • Molecular Biology
    • Genetics

    Context:

    • Oncovirus-cell interactions are critical in viral oncogenesis.
    • Understanding these interactions aids in developing targeted cancer therapies.

    Purpose:

    • To review the key factors driving genetic instability within the oncovirus-cell system.
    • To elucidate the mechanisms by which viruses induce cellular genetic alterations.

    Summary:

    • The review covers the expression of early viral genes (e.g., adenoviruses) and their interplay with cellular genes.
    • It discusses the activation of cellular genes and genetic elements in infected cells.
    • Mechanisms of DNA repair inhibition by viral components and modified bases are also detailed.

    Impact:

    • Provides a comprehensive overview of genetic instability in viral carcinogenesis.
    • Highlights potential therapeutic targets for oncovirus-associated cancers.

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