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Calcification in human breast carcinomas: ultrastructural observations.
The Journal of Pathology
|December 1, 1975
Summary
Calcification in breast cancer involves needle-shaped hydroxyapatite crystals, likely from an active secretory process, not cell death. This finding offers new insights into tumor microenvironment composition.
Area of Science:
- Oncology
- Biomineralization
- Electron Microscopy
Background:
- Calcification is observed in human breast carcinomas.
- The ultrastructural basis and origin of this calcification remain unclear.
Purpose of the Study:
- To investigate the ultrastructural characteristics of calcification in human breast carcinomas.
- To determine the composition and potential origin of these calcifications.
Main Methods:
- Ultrastructural analysis using electron microscopy.
- Electron diffraction and electron probe analysis to identify crystal composition.
Main Results:
- Needle-shaped hydroxyapatite crystals were found within tumor cells and the surrounding stroma.
- Calcification occurred in cytoplasmic vesicles and as crystal clusters.
- Evidence suggests an active secretory process rather than calcified necrotic cells.
Conclusions:
- Breast carcinoma calcification is primarily hydroxyapatite.
- The process appears to be an active secretion by tumor cells.
- Understanding this mechanism may offer new diagnostic or therapeutic avenues.