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Updated: Aug 11, 2026
07:55
High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing
Published on: May 21, 2020
Yeast go the whole HOG for the hyperosmotic response
Sean M O'Rourke1, Ira Herskowitz, Erin K O'Shea
1Dept of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.
Trends in Genetics : TIG
|July 27, 2002
Summary
The high osmolarity glycerol (HOG) pathway in yeast cells activates a signaling cascade to manage osmotic stress. This conserved pathway involves osmosensors and transcription factors to regulate gene expression during stress.
Area of Science:
- Cellular biology
- Molecular biology
- Stress response pathways
Background:
- The high osmolarity glycerol (HOG) pathway is crucial for yeast's response to osmotic stress.
- This evolutionarily conserved pathway is well-studied in Saccharomyces cerevisiae.
Purpose of the Study:
- To elucidate the comprehensive mechanisms of the HOG pathway in yeast.
- To understand how cells signal and respond to hyperosmotic stress.
Main Methods:
- Utilized a variety of powerful experimental approaches.
- Investigated cell surface osmosensors and downstream signaling components.
Main Results:
- Identified key osmosensors involved in initiating the stress response.
- Characterized the signaling cascade leading to transcriptional changes.
- Demonstrated the regulation of transcription factors by the HOG pathway.
Conclusions:
- The HOG pathway is a central regulator of the hyperosmotic stress response in yeast.
- Cell surface osmosensors play a critical role in activating downstream signaling.
- The pathway ultimately controls gene expression to adapt to osmotic challenges.
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